Empirical mode decomposition of local field potential data from optogenetic experiments

Introduction This study investigated the effects of cocaine administration and parvalbumin-type interneuron stimulation on local field potentials (LFPs) recorded in vivo from medial prefrontal cortex (mPFC) six mice using optogenetic tools. Methods The network was subject to a brief 10 ms laser pulse, response for 2 s over 100 trials each subjects who showed stable coupling between mPFC optrode. Due strong non-stationary nonlinearity LFP, we used adaptive, data-driven, Empirical Mode Decomposition (EMD) method decompose signal into orthogonal Intrinsic Functions (IMFs). Results Through trial error, found that seven is optimum number IMFs overlaps with known frequency bands brain activity. We Index Orthogonality (IO) IMF amplitudes close zero. Energy Conservation (IEC) decomposition unity, as expected decompositions. power density distribution vs. follows law an average scaling exponent ~1.4 entire range frequencies 2–2,000 Hz. Discussion slightly smaller than control, suggesting neural activity avalanches under have longer life spans sizes.